Hematology: Basic Principles and Practice, Expert Consult - Online and Print (Expert Consult Title: Online + Print), 5th Edition

Cover......Page 1
Contributors
......Page 8
Preface
......Page 20
1 - ANATOMY AND PHYSIOLOGY OF THE GENE......Page 23
2 - GENOMIC APPROACHES TO THE STUDY OF HEMATOLOGIC SCIENCE......Page 36
3 - PROTEIN SYNTHESIS, PROCESSING, AND TRAFFICKING......Page 45
4 - PROTEIN DEGRADATION IN CELLS......Page 54
5 - PROTEIN ARCHITECTURE: RELATIONSHIP OF FORM AND FUNCTION......Page 62
6 - REGULATION OF CELLULAR RESPONSE......Page 69
7 - CONTROL OF CELL DIVISION......Page 81
8 - CELL DEATH......Page 92
9 - PHARMACOGENOMICS AND HEMATOLOGIC DISEASES......Page 101
10 - OVERVIEW AND COMPARTMENTALIZATION OF THE IMMUNE SYSTEM......Page 115
11 - B-CELL DEVELOPMENT......Page 125
12 - T-CELL IMMUNITY......Page 137
13 - NATURAL KILLER CELL IMMUNITY......Page 149
14 - DENDRITIC CELL BIOLOGY......Page 155
15 - REGULATION OF ACTIVATION OF B AND T LYMPHOCYTES......Page 164
16 - CELL ADHESION......Page 181
17 - CELL TRAFFICKING AND CHEMOKINES......Page 189
18 - TOLERANCE AND AUTOIMMUNITY......Page 196
19 - OVERVIEW OF STEM CELL BIOLOGY......Page 207
20 - CELLULAR BIOLOGY OF HEMATOPOIESIS......Page 220
21 - TRANSCRIPTION FACTORS IN NORMAL AND MALIGNANT HEMATOPOIESIS......Page 233
22 - NONHEMATOPOIETIC STEM CELLS ORIGINATING WITHIN THE BONE MARROW......Page 251
23 - INTERACTIONS BETWEEN HEMATOPOIETIC STEM/PROGENITOR CELLS AND THE BONE MARROW: THE BIOLOGY OF STEM CELL HOMING AND MOBILIZATION......Page 265
24 - THE HUMORAL REGULATION OF HEMATOPOIESIS......Page 273
25 - BIOLOGY OF ERYTHROPOIESIS, ERYTHROID DIFFERENTIATION, AND MATURATION......Page 296
26 - GRANULOCYTOPOIESIS AND MONOCYTOPOIESIS......Page 315
27 - THROMBOCYTOPOIESIS......Page 325
28 - INHERITED FORMS OF BONE MARROW FAILURE......Page 339
29 - APLASTIC ANEMIA......Page 378
30 - PAROXYSMAL NOCTURNAL HEMOGLOBINURIA......Page 403
31 - ACQUIRED DISORDERS OF RED CELL AND WHITE CELL PRODUCTION......Page 415
32 - THROMBOCYTOPENIA DUE TO DECREASED PLATELET PRODUCTION......Page 431
33 - PATHOBIOLOGY OF THE HUMAN ERYTHROCYTE AND ITS HEMOGLOBINS......Page 447
34 - APPROACH TO ANEMIA IN THE ADULT AND CHILD......Page 459
35 - PATHOLOGY OF IRON METABOLISM......Page 467
36 - DISORDERS OF IRON METABOLISM: IRON DEFICIENCY AND IRON OVERLOAD......Page 473
37 - ANEMIA OF CHRONIC DISEASES......Page 489
38 - HEME BIOSYNTHESIS AND ITS DISORDERS: Porphyrias and Sideroblastic Anemias......Page 495
39 - MEGALOBLASTIC ANEMIAS......Page 511
40 - LABORATORY DIAGNOSIS OF HEMOGLOBINOPATHIES AND THALASSEMIAS......Page 545
41 - THALASSEMIA SYNDROMES......Page 555
42 - PATHOBIOLOGY OF SICKLE CELL DISEASE......Page 585
43 - SICKLE CELL DISEASE—CLINICAL FEATURES AND MANAGEMENT......Page 597
44 - HEMOGLOBIN VARIANTS ASSOCIATED WITH HEMOLYTIC ANEMIA, ALTERED OXYGEN AFFINITY, AND METHEMOGLOBINEMIAS......Page 623
45 - RED BLOOD CELL ENZYMOPATHIES......Page 631
46 - RED BLOOD CELL MEMBRANE DISORDERS......Page 643
47 - AUTOIMMUNE HEMOLYTIC ANEMIA......Page 665
48 - EXTRINSIC NONIMMUNE HEMOLYTIC ANEMIAS......Page 679
49 - COMPLEMENT AND IMMUNOGLOBULIN BIOLOGY......Page 691
50 - DISORDERS OF PHAGOCYTE FUNCTION AND NUMBER......Page 707
51 - DISORDERS OF LYMPHOCYTE FUNCTION......Page 741
52 - HISTIOCYTIC DISORDERS......Page 767
53 - LYSOSOMAL STORAGE DISEASES: PERSPECTIVES AND PRINCIPLES......Page 781
54 - INFECTIOUS MONONUCLEOSIS AND OTHER EPSTEIN–BARR VIRUS-ASSOCIATED DISEASES......Page 799
55 - CONVENTIONAL AND MOLECULAR CYTOGENETIC BASIS OF HEMATOLOGIC MALIGNANCIES......Page 811
56 - PHARMACOLOGY AND MOLECULAR MECHANISMS OF ANTINEOPLASTIC AGENTS FOR HEMATOLOGIC MALIGNANCIES......Page 859
57 - RADIATION THERAPY IN THE TREATMENT OF HEMATOLOGIC MALIGNANCIES......Page 919
58 - CLINICAL USE OF HEMATOPOIETIC GROWTH FACTORS......Page 927
59 - PATHOBIOLOGY OF ACUTE MYELOID LEUKEMIA......Page 941
60 - CLINICAL MANIFESTATIONS OF ACUTE MYELOID LEUKEMIA......Page 953
61 - THERAPY FOR ACUTE MYELOID LEUKEMIA......Page 985
62 - ACUTE MYELOID LEUKEMIA IN CHILDREN......Page 1011
63 - PATHOBIOLOGY OF ACUTE LYMPHOBLASTIC LEUKEMIA......Page 1023
64 - CLINICAL MANIFESTATIONS OF ACUTE LYMPHOBLASTIC LEUKEMIA......Page 1039
65 - TREATMENT OF CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA......Page 1047
66 - ACUTE LYMPHOCYTIC LEUKEMIA IN ADULTS......Page 1053
67 - MYELODYSPLASTIC SYNDROMES: BIOLOGY AND TREATMENT......Page 1071
68 - THE POLYCYTHEMIAS......Page 1093
69 - CHRONIC MYELOID LEUKEMIA......Page 1129
70 - PRIMARY MYELOFIBROSIS......Page 1145
71 - ESSENTIAL THROMBOCYTHEMIA......Page 1169
72 - EOSINOPHILIA, EOSINOPHIL-ASSOCIATED DISEASES, CHRONIC EOSINOPHIL LEUKEMIA, AND THE HYPEREOSINOPHILIC SYNDROMES......Page 1187
73 - MAST CELLS AND SYSTEMIC MASTOCYTOSIS......Page 1207
74 - MYELODYSPLASTIC AND MYELOPROLIFERATIVE SYNDROMES IN CHILDREN......Page 1219
75 - PATHOBIOLOGY OF NON-HODGKIN LYMPHOMA......Page 1227
76 - PATHOBIOLOGY OF HODGKIN LYMPHOMA......Page 1241
77 - HODGKIN LYMPHOMA......Page 1259
78 - THE PATHOLOGIC BASIS FOR THE CLASSIFICATION OF NON-HODGKIN LYMPHOMAS......Page 1285
79 - CLINICAL MANIFESTATIONS, STAGING, AND TREATMENT OF INDOLENT NON-HODGKIN LYMPHOMA......Page 1301
80 - DIAGNOSIS AND TREATMENT OF NON-HODGKIN LYMPHOMA (AGGRESSIVE)......Page 1313
81 - MALIGNANT LYMPHOMAS IN CHILDHOOD......Page 1323
82 - RADIOIMMUNOTHERAPY FOR B-CELL NON-HODGKIN LYMPHOMA......Page 1335
83 - CHRONIC LYMPHOCYTIC LEUKEMIA......Page 1347
84 - HAIRY CELL LEUKEMIA......Page 1369
85 - CUTANEOUS T-CELL LYMPHOMAS......Page 1379
86 - AIDS-RELATED LYMPHOMAS......Page 1397
87 - MULTIPLE MYELOMA......Page 1407
88 - WALDENSTR?M MACROGLOBULINEMIA/LYMPHOPLASMACYTIC LYMPHOMA......Page 1433
89 - IMMUNOGLOBULIN LIGHT-CHAIN AMYLOIDOSIS (PRIMARY AMYLOIDOSIS)......Page 1445
90 - ATYPICAL IMMUNE LYMPHOPROLIFERATIONS......Page 1469
91 - CLINICAL APPROACH TO INFECTIONS IN THE COMPROMISED HOST......Page 1481
92 - NUTRITIONAL SUPPORT OF PATIENTS WITH HEMATOLOGIC MALIGNANCIES......Page 1495
93 - PSYCHOSOCIAL ASPECTS OF HEMATOLOGIC DISORDERS......Page 1511
94 - PAIN MANAGEMENT AND ANTIEMETIC THERAPY IN HEMATOLOGIC DISORDERS......Page 1521
95 - PALLIATIVE CARE......Page 1537
96 - INDWELLING ACCESS DEVICES......Page 1545
97 - LATE COMPLICATIONS OF HEMATOLOGIC DISEASES AND THEIR THERAPIES......Page 1559
98 - OVERVIEW OF CELL- AND IMMUNE-BASED THERAPIES......Page 1575
99 - HEMATOPOIETIC STEM CELL TRANSPLANTATION FOR ACQUIRED NONMALIGNANT DISEASES AND MYELODYSPLASTIC SYNDROME......Page 1581
100 - HEMATOPOIETIC STEM CELL TRANSPLANTATION FOR IMMUNE DEFICIENCIES AND GENETIC DISORDERS......Page 1597
101 - OUTCOMES OF ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANTATION FOR HEMATOLOGIC MALIGNANCIES IN ADULTS......Page 1607
102 - AUTOLOGOUS TRANSPLANTATION FOR HEMATOLOGIC MALIGNANCIES......Page 1625
103 - UNRELATED DONOR HEMATOPOIETIC CELL TRANSPLANTATION......Page 1639
104 - HAPLOIDENTICAL HEMATOPOIETIC CELL TRANSPLANTATION......Page 1653
105 - UMBILICAL CORD BLOOD TRANSPLANTATION......Page 1663
106 - PREPARATIVE REGIMENS FOR HEMATOPOIETIC CELL TRANSPLANTATION......Page 1685
107 - GRAFT-VERSUS-HOST DISEASE AND GRAFT-VERSUS-LEUKEMIA RESPONSES......Page 1697
108 - PRACTICAL ASPECTS OF STEM CELL COLLECTION......Page 1715
109 - GRAFT ENGINEERING AND CELL PROCESSING......Page 1733
110 - GENE TRANSFER FOR HEMATOLOGIC DISORDERS......Page 1743
111 - EXPERIMENTAL CELL THERAPY......Page 1755
112 - STEM CELLS FOR TISSUE REPAIR......Page 1767
113 - COMPLICATIONS AFTER HEMATOPOIETIC CELL TRANSPLANTATION......Page 1775
114 - MEGAKARYOCYTE AND PLATELET STRUCTURE......Page 1791
115 - THE MOLECULAR BASIS OF PLATELET FUNCTION......Page 1801
116 - THE MOLECULAR BASIS OF PLATELET ACTIVATION......Page 1813
117 - THE BLOOD VESSEL WALL......Page 1825
118 - MOLECULAR BASIS OF BLOOD COAGULATION......Page 1839
119 - MOLECULAR AND CELLULAR BASIS OF FIBRINOLYSIS......Page 1857
120 - REGULATORY MECHANISMS IN HEMOSTASIS: NATURAL ANTICOAGULANTS......Page 1863
121 - CLINICAL EVALUATION OF HEMORRHAGIC DISORDERS: THE BLEEDING HISTORY AND DIFFERENTIAL DIAGNOSIS OF PURPURA......Page 1871
122 - LABORATORY EVALUATION OF HEMOSTATIC AND THROMBOTIC DISORDERS......Page 1897
123 - STRUCTURE, BIOLOGY, AND GENETICS OF FACTOR VIII......Page 1905
124 - BIOCHEMISTRY OF FACTOR IX AND MOLECULAR BIOLOGY OF HEMOPHILIA B......Page 1919
125 - CLINICAL ASPECTS AND THERAPY FOR HEMOPHILIA......Page 1931
126 - INHIBITORS IN HEMOPHILIA A AND B......Page 1951
127 - RARE COAGULATION FACTOR DEFICIENCIES......Page 1959
128 - STRUCTURE, BIOLOGY, AND GENETICS OF VON WILLEBRAND FACTOR......Page 1973
129 - VON WILLEBRAND DISEASE: CLINICAL ASPECTS AND THERAPY......Page 1981
130 - VITAMIN K: METABOLISM AND DISORDERS......Page 1993
131 - LUPUS ANTICOAGULANT AND ACQUIRED INHIBITORS OF BLOOD COAGULATION......Page 1999
132 - DISSEMINATED INTRAVASCULAR COAGULATION......Page 2019
133 - DISORDERS OF COAGULATION IN THE NEONATE......Page 2031
134 - HYPERCOAGULABLE STATES......Page 2041
135 - VENOUS THROMBOEMBOLISM......Page 2063
136 - ARTERIAL THROMBOEMBOLISM......Page 2075
137 - ANTITHROMBOTIC DRUGS......Page 2087
138 - IMMUNE THROMBOCYTOPENIC PURPURA, NEONATAL ALLOIMMUNE THROMBOCYTOPENIA, AND POSTTRANSFUSION PURPURA......Page 2103
139 - THROMBOTIC THROMBOCYTOPENIC PURPURA AND THE HEMOLYTIC UREMIC SYNDROME......Page 2119
140 - THROMBOCYTOPENIA DUE TO PLATELET DESTRUCTION AND HYPERSPLENISM......Page 2133
141 - HEREDITARY DISORDERS OF PLATELET FUNCTION......Page 2153
142 - ACQUIRED DISORDERS OF PLATELET FUNCTION......Page 2165
143 - HUMAN BLOOD GROUP ANTIGENS AND ANTIBODIES......Page 2183
144 - HUMAN PLATELET ANTIGENS......Page 2199
145 - HUMAN LEUKOCYTE ANTIGEN AND HUMAN NEUTROPHIL ANTIGEN SYSTEMS......Page 2211
146 - PRINCIPLES OF RED BLOOD CELL TRANSFUSION......Page 2229
147 - PRINCIPLES OF PLATELET TRANSFUSION THERAPY......Page 2239
148 - PRINCIPLES OF NEUTROPHIL (GRANULOCYTE) TRANSFUSIONS......Page 2245
149 - TRANSFUSION OF PLASMA DERIVATIVES: FRESH-FROZEN PLASMA, CRYOPRECIPITATE, ALBUMIN, AND IMMUNOGLOBULINS......Page 2251
150 - PREPARATION OF PLASMA-DERIVED AND RECOMBINANT HUMAN PLASMA PROTEINS......Page 2259
151 - TRANSFUSION THERAPY FOR COAGULATION FACTOR DEFICIENCIES......Page 2267
152 - HEMAPHERESIS AND CELLULAR THERAPY......Page 2277
153 - TRANSFUSION REACTIONS......Page 2287
154 - TRANSFUSION-TRANSMITTED DISEASES......Page 2297
155 - TRANSFUSION MEDICINE IN HEMATOPOIETIC STEM CELL AND SOLID ORGAN TRANSPLANTATION......Page 2311
156 - HEMATOLOGIC MANIFESTATIONS OF SYSTEMIC DISEASE: LIVER AND RENAL DISEASE......Page 2323
157 - HEMATOLOGIC MANIFESTATIONS OF SYSTEMIC DISEASE: INFECTION, CHRONIC INFLAMMATION, AND CANCER......Page 2329
158 - HEMATOLOGIC MANIFESTATIONS OF AIDS......Page 2341
159 - HEMATOLOGIC ASPECTS OF PARASITIC DISEASES......Page 2361
160 - HEMATOLOGIC PROBLEMS IN THE SURGICAL PATIENT: BLEEDING AND THROMBOSIS......Page 2389
161 - HEMATOLOGIC CHANGES OF PREGNANCY......Page 2405
162 - HEMATOLOGIC MANIFESTATIONS OF CHILDHOOD ILLNESS......Page 2417
163 - THE SPLEEN AND ITS DISORDERS......Page 2439
164 - APPENDIX: NORMAL BLOOD VALUES: SELECTED REFERENCE VALUES FOR NEONATAL, PEDIATRIC, AND ADULT POPULATIONS......Page 2451
Index
......Page 2463