Submarine Exposure Guidance Levels for Selected Hydrofluorocarbons: HFC-236fa, HFC-23, and HFC-404a

SUBMARINE EXPOSURE GUIDANCE LEVELS FOR SELECTED HYDROFLUOROCARBONS......Page 2
Copyright......Page 3
Contents......Page 14
Summary......Page 18
APPROACH TO THE STUDY......Page 19
CONCLUSIONS AND RECOMMENDATIONS......Page 20
HFC-236FA......Page 21
HFC-404A......Page 22
Exposure Guidance Levels for Components of HFC-404a......Page 23
Exposure Guidance Levels for HFC-404a......Page 24
1 Introduction......Page 26
EXPOSURE GUIDANCE LEVELS......Page 27
Emergency Exposure Guidance Levels......Page 28
Special Considerations......Page 29
REFERENCES......Page 30
CHEMICAL AND PHYSICAL PROPERTIES......Page 31
TOXICOKINETICS......Page 32
Acute Toxicity......Page 33
Cardiac Sensitization......Page 34
Subchronic Toxicity......Page 35
Developmental Toxicity......Page 37
SUMMARY......Page 38
EXPOSURE GUIDANCE LEVELS......Page 39
RECOMMENDATIONS......Page 42
REFERENCES......Page 43
CHEMICAL AND PHYSICAL PROPERTIES......Page 44
TOXICOKINETICS......Page 45
Acute Toxicity......Page 46
Cardiac Sensitization......Page 47
Reproductive Toxicity......Page 48
Genotoxicity......Page 49
Carcinogenicity......Page 50
SUMMARY......Page 51
EXPOSURE GUIDANCE LEVELS......Page 53
REFERENCES......Page 54
4 Hydrofluorocarbon-404a......Page 57
Toxicokinetics......Page 58
Subchronic Toxicity......Page 59
Developmental Toxicity......Page 60
Genotoxicity......Page 61
Exposure Guidance Levels for HFC-143a......Page 62
Chemical and Physical Properties......Page 64
Acute Toxicity......Page 65
Cardiac Sensitization......Page 66
Developmental Toxicity......Page 67
Genotoxicity......Page 68
Exposure Guidance Levels for HFC-125......Page 69
Chemical and Physical Properties......Page 71
Toxicokinetics......Page 72
Human Studies......Page 74
Cardiac Sensitization......Page 77
Subchronic Toxicity......Page 78
Reproductive and Developmental Toxicity......Page 79
Genotoxicity......Page 81
Carcinogenicity......Page 82
Exposure Guidance Levels for HFC-134a......Page 83
SUMMARY......Page 88
EXPOSURE GUIDANCE LEVELS FOR HFC-404A......Page 90
Calculations Used to Determine EEGLs and CEGL for HFC-404a......Page 91
REFERENCES......Page 93